AVPR2 Rabbit pAb, BF488 conjugated(bs-10014R-BF488)-100ul

AVPR2 Rabbit pAb, BF488 conjug

ated(bs-10014R-BF488)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-10014R-BF488
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格

      100ul

    产品编号bs-10014R-BF488
    英文名称AVPR2 Rabbit pAb, BF488 conjugated
    中文名称BF488标记的精氨酸加压素受体2抗体
    英文别名arginine vasopressin receptor 2; ADHR; Antidiuretic hormone recepto; Arginine vasopressin receptor 2; AVP R2; AVPR 2; AVPR V2; DI1; DIR 3; DIR; DIR3; MGC126533; MGC138386; NDI; Nephrogenic diabetes insipidus; Renal type arginine vasopressin recepto; V2R; Vasopressin V2 receptor.
    产品应用Flow-Cyt=2ug/Test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human AVPR2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Neurology process > Neuroendocrinology > Oxytocin & Vasopressin

    Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR

    Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Vasopressin receptor

    亚细胞定位Cell membrane; Multi-pass membrane protein.
    组织特异性Kidney.
    相似性Belongs to the G-protein coupled receptor 1 family.
    Vasopressin/oxytocin receptor subfamily.
    功能Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {Flow-Cyt}{2ug/Test}

     

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