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- Bioss
- bs-0268R-Cy5
- 2025年09月30日
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100ul
| 产品编号 | bs-0268R-Cy5 |
| 英文名称 | Neurobeachin Rabbit pAb, Cy5 conjugated |
| 中文名称 | Cy5标记的蛋白激酶锚定蛋白抗体 |
| 英文别名 | A-kinase anchor protein 550; d AKAP 550; Neurobeachin protein; Rugose protein; AKAP550; NBEA_DROME. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from Fruit fly Neurobeachin |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > PKA Signal Transduction > Protein Trafficking > Organelle Proteins |
| 亚基 | Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways. |
| 亚细胞定位 | Cytoplasm. Membrane; Peripheral membrane protein._x000D_ |
| 组织特异性 | In early embryos, ubiquitous expression with elevated levels in ventral furrow and flanking mesectodermal cells, neuroblasts and mesoderm. Late embryos show reduced expression in epidermis and skeletal muscle and elevated in nervous system, gut endothelium, tracheal system and salivary gland. Larvae show expression in imaginal disks and many neural cells. Developing eye imaginal disk shows expression throughout the disk and in the region of the morphogenetic furrow. Ubiquitous expression in adults with higher levels in head region. |
| 相似性 | Belongs to the WD repeat neurobeachin family. Contains 1 BEACH domain. Contains 5 WD repeats._x000D_ |
| 功能 | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Neurobeachin binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. It may anchor the kinase to cytoskeletal and/or organelle-associated proteins. Neurobeachin, is also a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site for the type II regulatory subunit of protein kinase A. Neurobeachin is peripherally associated with pleomorphic tubulovesicular endomembranes near the trans sides of Golgi stacks and throughout the cell body and cell processes. It is also found in a subpopulation of synapses, where it is concentrated at the postsynaptic plasma membrane. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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Neurobeachin Rabbit pAb, Cy5 conjugated(bs-0268R-Cy5)-100ul
￥2980
