NR4A2 | NURR1 Rabbit pAb, BF750 conj.(bs-20744R-BF750)-100ul产品图

NR4A2 | NURR1 Rabbit pAb, BF75

0 conj.(bs-20744R-BF750)-100ul
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  • bs-20744R-BF750
  • 2026年10月14日
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      100ul

    产品编号bs-20744R-BF750
    英文名称Nurr1 Rabbit pAb, BF750 conjugated
    中文名称BF750标记的核受体相关因子-1抗体
    英文别名Nur-ralated factor 1; Nuclear receptor-related factor 1; Orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; Regenerating liver nuclear receptor 1; RNR-1; SL-322; Nuclear orphan receptor HZF-3; T-cell nuclear receptor NOT; HZF 3; HZF3; Immediate-early response protein NOT; Intermediate early receptor protein; NGFI B/nur77 beta type transcription factor homolog; NOT; NR4A2; NR4A2_HUMAN; Nuclear receptor subfamily 4 group A member 2; Nur related protein 1 homolog; Nurr 1; RNR 1; RNR1; TINUR; Transcriptionally inducible nuclear receptor; Transcriptionally inducible nuclear receptor related; Transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Nurr1
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Response to hypoxia

    Epigenetics and Nuclear Signaling > Transcription > Other factors

    Immunology > Immune System Diseases > Autoimmune

    Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

    Metabolism > Types of disease > Cancer

    Neuroscience > Neurology process > Neural Signal Transduction

    Neuroscience > Neurology process > Neurodegenerative disease > Parkinson's disease

    Neuroscience > Neurology process > Neurogenesis

    亚基Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3 (By similarity).
    亚细胞定位Nucleus.
    组织特异性Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
    相似性Belongs to the nuclear hormone receptor family. NR4 subfamily.
    _x000D_ Contains 1 nuclear receptor DNA-binding domain.
    功能Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Nuclear receptor and transcription factor; plays a role in development and maintenance of neurons synthesizing the neurotransmitter dopamine This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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