- ￥2980
- Bioss
- bs-0667R-FITC
- 2025年09月30日
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100ul
| 产品编号 | bs-0667R-FITC |
| 英文名称 | Smac Rabbit pAb, FITC conjugated |
| 中文名称 | FITC标记的线粒体促凋亡蛋白抗体 |
| 英文别名 | Smac/Diablo; 0610041G12Rik; DBLOH_HUMAN; DBOH; DBOH; diablo; Diablo homolog(Drosophila); Diablo homolog(Drosophila); Diablo homolog; Diablo homolog Drosophila; Diablo homolog mitochondrial; Diablo homolog mitochondrial precursor; DIABLO S; DIABLO S; DIABLOS; Direct IAP binding protein with low pI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; mitochondrial; Mitochondrial Smac protein; Second Mitochondria Derived Activator of Caspase; Second mitochondria-derived activator of caspase; SMAC 3; smac; Smac protein; SMAC3. |
| 产品应用 | ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Smac |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Mitochondrial Cancer > Cell Death > Apoptosis > Receptors > Death receptors & ligands > IAPs Cancer > Invasion/microenvironment > Apoptosis > Death receptors & ligands > IAPs Cell Biology > Apoptosis > Mitochondrial Cell Biology > Apoptosis > Receptors > Death Receptors Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers |
| 亚基 | Homodimer. Interacts with NGFRAP1/BEX3 (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Interacts with the monomeric and dimeric form of BIRC5/survivin. |
| 亚细胞定位 | Mitochondrion. Note=Released into the cytosol when cells undergo apoptosis. |
| 组织特异性 | Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. |
| 翻译后修饰 | Ubiquitinated by BIRC7/livin. |
| 功能 | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-1298P is one synthetic peptide derived from human Smac. This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. The inhibitor of apoptosis (IAP) proteins regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes their inhibitory effect on caspases has been designated Smac/DIABLO. This is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
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Smac Rabbit pAb, FITC conjugated(bs-0667R-FITC)-100ul
￥2980
