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- Bioss
- bs-5898R-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-5898R-Cy7 |
| 英文名称 | HIF3 alpha Rabbit pAb, Cy7 conjugated |
| 中文名称 | Cy7标记的缺氧诱导因子3α/HIF-3α抗体 |
| 英文别名 | HIF 3 alpha; HIF-3 alpha; HIF 3A; HIF 3A4; HIF3 alpha; HIF3A; HIF 3A; HIF-3A; Hypoxia Inducible Factor 3 alpha; Hypoxia inducible factor 3 alpha subunit; Hypoxia inducible factor three alpha; Inhibitory PAS domain protein; IPAS; MOP7; PASD7. |
| 产品应用 | IF=1:100-500, ICC/IF=1:50-200 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HIF3 alpha |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > Hypoxia > HIF Cardiovascular > Hypoxia > HIF Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > HIF Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH |
| 亚基 | Heterodimerizes with ARNT. Interacts via the oxygen-dependent degradation domain (ODD) with the beta domain of VHL. |
| 亚细胞定位 | Nucleus. Cytoplasm. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. |
| 组织特异性 | Expressed in kidney. Expressed abundantly in lung epithelial cells. Expression is regulated in an oxygen-dependent manner. |
| 相似性 | Contains 1 basic helix-loop-helix (bHLH) domain. Contains 2 PAS (PER-ARNT-SIM) domains. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Hypoxia-inducible factor (HIF) is one of the most important factors in the cellular response to hypoxia, transcriptionally activating genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits, HIF1 alpha, HIF2 alpha, or HIF3 alpha. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation and cell survival. HIF3 alpha protein is one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha 1 or alpha 2 subunits. HIF3 alpha may be a marker for tumor growth and angiogenesis. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
| {ICC/IF} | {1:50-200} |
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HIF3 alpha Rabbit pAb, Cy7 conjugated(bs-5898R-Cy7)-100ul
￥2980
