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- bs-14061R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-14061R-AP |
| 英文名称 | CRISP11 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的富含半胱氨酸分泌蛋白11抗体 |
| 英文别名 | CRISP-11; CRISPLD2; CRISP11; Crispld2; CRLD2_HUMAN; Cysteine-rich secretory protein 11; Cysteine-rich secretory protein LCCL domain-containing 2; DKFZP434B044; LCCL domain-containing cysteine-rich secretory protein 2; LCRISP2; LCRISP2; MGC74865. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CRISP11 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Other ECM Proteins |
| 亚细胞定位 | Secreted. |
| 相似性 | Belongs to the CRISP family. _x000D_ Contains 2 LCCL domains. |
| 功能 | Promotes matrix assembly. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins that may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. CRISP proteins are highly expressed in the mammalian reproductive tract and in the venom secretory ducts of some reptiles. CRISP-11 (cysteine-rich secretory protein 11), also known as cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2 or LCRISP2), is a 497 amino acid protein containing 2 LCCL domains, which are thought to function as autonomous folding domains used to construct modular proteins through exon shuffling. Serum concentrations of CRISP-11 have been shown to be an indicator of a patient’s exposure to lipopolysaccahride (LPS), the immunostimulatory component of Gram-negative bacteria, and can determine one’s sensitivity to it. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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文献和实验Using ProHits to Store, Annotate, and Analyze Affinity Purification–Mass Spectrometry (AP‐MS) Data
., and Honkanen, R.E. 2011. Label‐free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. Proteomics 11:1508‐1516. Stark
Immunity：北大蒋争凡课题组发现 STING 后高尔基体囊泡转运的重要性及机制
： https://doi.org/10.1016/j.immuni.2023.02.004 参考文献： 1 Fang, R. et al. Recent advances in the activation and regulation of the cGAS-STING pathway. Advances in Immunology 156, 55-102, doi:10.1016 /bs.ai.2022.09.003 (2022). 2 Posor, Y. et al.
. P. Bartel, MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281–297 (2004).[CrossRef][Medline] 3. W. P. Kloosterman, R. H. Plasterk, The diverse functions of microRNAs in animal development and disease. Dev. Cell 11, 441–450
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