Cytochrome C Mouse mAb, PE-Cy7 conjugated(bsm-33193M-PE-Cy7)-100ul

Cytochrome C Mouse mAb, PE-Cy7

conjugated(bsm-33193M-PE-Cy7)-100ul
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  • ¥2980
  • Bioss已认证
  • bsm-33193M-PE-Cy7
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格

      100ul

    产品编号bsm-33193M-PE-Cy7
    英文名称Cytochrome C Mouse mAb, PE-Cy7 conjugated
    中文名称PE-Cy7标记的细胞色素C单克隆抗体
    英文别名CytC; CYC; CYCS; Cytochrome c somatic; HCS; CYC_HUMAN; Cytochrome c; MSA06; THC4.
    产品应用ICC/IF=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Mouse
    免疫原Recombinant human Cytochrome C Protein
    亚型IgG
    纯化方法affinity purified by Protein G
    克隆类型Monoclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism

    Cancer > Cell Death > Apoptosis > Apoptosis Markers > Cytochrome C

    Cancer > Cell Death > Apoptosis > Metabolism

    Cancer > Cell Death > Apoptosis > Mitochondrial

    Cancer > Invasion/microenvironment > Apoptosis > Cytochrome C

    Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cytochromes

    Cell Biology > Apoptosis > Mitochondrial

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases

    Metabolism > Pathways and Processes > Metabolism processes > Apoptosis

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Cytochromes

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Oxidative phosphorylation

    Signal Transduction > Metabolism > Energy Metabolism

    Signal Transduction > Metabolism > Mitochondrial

    亚细胞定位

    Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

    翻译后修饰

    Binds 1 heme c group covalently per subunit.
    Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

    相似性

    Belongs to the cytochrome c family.

    功能

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.

     

    应用推荐稀释比例
    {ICC/IF}{1:100-500}
    {IF}{1:100-500}

     

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