NTN3 | Netrin-3 Rabbit pAb, Biotin conj.(bs-11059R-Bio)-100ul产品图

NTN3 | Netrin-3 Rabbit pAb, Bi

otin conj.(bs-11059R-Bio)-100ul
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  • bs-11059R-Bio
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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      100ul

    产品编号bs-11059R-Bio
    英文名称NTN3 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的轴突生长诱导因子3抗体
    英文别名NET3_HUMAN; Netrin-2-like protein; Netrin3; Netrin-3; Netrin 3; NTN2L; NTN3.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human NTN3/Netrin-3
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Cell Adhesion Proteins > ECM Proteins

    Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins

    亚细胞定位Secreted; extracellular space; extracellular matrix.
    组织特异性Spinal cord. _x000D_
    相似性Contains 3 laminin EGF-like domains.
    Contains 1 laminin N-terminal domain.
    Contains 1 NTR domain.
    功能Netrins control guidance of CNS commissural axons and peripheral motor axons.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins as the cells are repelled, rather than attracted, by the netrin gradient. Neogenin serves as the primary guidance receptor for netrin-3. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin-3 proteins are associated with the axon fibers projecting from motor neurons and from neurons within sympathetic and sensory ganglia, suggesting that netrin-3 may be involved in pathfinding and fasciculation of axon projection. Neogenin serves as the primary guidance receptor for netrin-3. During peripheral nerve development, high netrin-3 expression has been detected in mesenchymal cells, sensory ganglia and muscles. In humans, the gene encoding for the netrin-3 protein is localized to chromosome 16p13.3.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

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