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TRF2 Rabbit pAb, Biotin conjug

ated(bs-22936R-Bio)-100ul
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  • ￥2980
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  • bs-22936R-Bio
  • 2025年09月30日
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      100ul

    产品编号bs-22936R-Bio
    英文名称TRF2 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的端粒结合蛋白2抗体
    英文别名Telomeric DNA binding protein; Telomeric repeat binding factor 2; Telomeric repeat binding protein 2; TERF 2; TERF2; TRBF 2; TRBF2; TRF 2; TTAGGG repeat binding factor 2.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from mouse TRF2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Oncoproteins/suppressors > Oncoproteins

    Epigenetics and Nuclear Signaling > Chromosome Structure > Telomeres

    Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes

    亚细胞定位Nucleus. Chromosome, telomere. Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
    组织特异性Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.
    翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    相似性Contains 1 HTH myb-type DNA-binding domain.
    功能Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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