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- Bioss
- bs-1508R-APC-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-1508R-APC-Cy5.5 |
| 英文名称 | Cathepsin L Rabbit pAb, APC-Cy5.5 conjugated |
| 中文名称 | APC-Cy5.5标记的组织蛋白酶L抗体 |
| 英文别名 | Cathepsin L heavy chain; Cathepsin L light chain; CathepsinL; CATL; CTSL; CTSL protein; DKFZp686A18159; FLJ31037; Major excreted protein; MEP; cath-L; CL; CATL1_HUMAN; CathepsinL1; Cathepsin L1, Cathepsin-L1; CTSL 1; CTSL-1, CTS L1, CTS-L1. |
| 产品应用 | Flow-Cyt=1ug/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human cathepsin L1 proprotein |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Cysteine protease > Cathepsins Neuroscience > Cell Adhesion Proteins > Membrane Proteins Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes |
| 亚基 | Dimer of a heavy and a light chain linked by disulfide bonds (Probable). Interacts with Long isoform of CD74/Ii chain; the interaction stabilizes the conformation of mature CTSL (PubMed:11483509, PubMed:12417635). |
| 亚细胞定位 | Lysosome. |
| 组织特异性 | Expressed in thymus, kidney and liver (PubMed:9545226). |
| 翻译后修饰 | During export along the endocytic pathway, pro-CTSL undergoes several proteolytic cleavages to generate the CTSL single-chain and two-chain mature forms, composed of a heavy chain linked to a light chain by disulfide bonds (PubMed:11483509). |
| 相似性 | Belongs to the peptidase C1 family. |
| 功能 | Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/Test} |
| {IF} | {1:100-500} |
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