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- bs-1297R-APC
- 2025年09月30日
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100ul
| 产品编号 | bs-1297R-APC |
| 英文名称 | CD28 Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的CD28抗体 |
| 英文别名 | CD 28; CD28 antigen; CD28 molecule; MGC138290; T cell antigen CD28; T cell specific surface glycoprotein; T cell specific surface glycoprotein CD28; Tp44; CD28_HUMAN; CD28_MOUSE. |
| 产品应用 | Flow-Cyt=1μg/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse CD28 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Adaptive Immunity > B Cells > CD Immunology > Adaptive Immunity > Regulatory T Cells Immunology > Adaptive Immunity > T Cells > CD Stem Cells > Hematopoietic Progenitors > Lymphoid > NK Cell Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage |
| 亚基 | Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Expressed in T-cells and plasma cells, but not in less mature B-cells. |
| 相似性 | Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Possibly involved in T-cell activation. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
| {IF} | {1:100-500} |
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文献和实验1. T、B细胞相互作用的过程T细胞为Th2亚群，而B细胞既是Th细胞辅助的对象，又是T细胞活化的APC。这一相互合作包括一系列过程：①抗原以其B表位(绿色)与BCR结合传递B细胞活化的第一信号，使其C1340与细胞因子受体的表达增加，并使B细胞加工提呈抗原和表达少量D7分子；②B细胞作为APC将带有T表位(红色)的抗原肽提呈给CD4T细胞，供T细胞识别；③初步活化的T细胞表达CD40L等，与B细胞表面CD40结合成为B细胞活化的第二信号；④活化B细胞表达B7分子与CD28结合为T细胞提供第二
Fluorochrome Absorption and Emission Spectra
light at 488 nm for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes
Fluorochrome Absorption and Emission
for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes are useful in experiments
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