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- bsm-33052M-Cy5.5
- 2026年04月16日
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100ul
| 产品编号 | bsm-33052M-Cy5.5 |
| 英文名称 | CD45 Mouse mAb, Cy5.5 conjugated |
| 中文名称 | Cy5.5标记的白细胞共同抗原CD45单克隆抗体 |
| 英文别名 | B220; CD 45; CD-45; CD45; cd45 antigen; ec3.1.3.48; CD45R; GP180; GP180; GP 180; L CA; LCA; L-CA; Leukocyte common antigen; LY5; Ly-5 glycoprotein; Protein tyrosine phosphatase receptor type C; Protein tyrosine phosphatase receptor type c polypeptide; protein tyrosine phosphatase, receptor type, C; Receptor-type tyrosine-protein phosphatase C; PTPRC; PTPRC_HUMAN; SCID due to PTPRC deficiency; T200; T200 glycoprotein; T200 leukocyte common antigen; Human homolog of severe combined immunodeficiency due to PTPRC deficiency. |
| 产品应用 | Flow-Cyt=1ug/test Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant human CD45 |
| 亚型 | IgG1 |
| 纯化方法 | affinity purified by Protein G |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Endothelial Cell Markers Immunology > Adaptive Immunity > B Cells > CD Immunology > Adaptive Immunity > Regulatory T Cells Immunology > Adaptive Immunity > T Cells > CD Immunology > Cell Type Markers > CD > Non-lineage Neuroscience > Cell Type Marker > Glia marker > Microglia marker Signal Transduction > Protein Phosphorylation > Tyrosine Phosphatases Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > NK Cell Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Dendritic Cell Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Mast Cell Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Neutrophil Lineage Stem Cells > Hematopoietic Progenitors > Surface Molecules |
| 亚基 | Binds GANAB and PRKCSH. Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes._x000D_ Contains 2 tyrosine-protein phosphatase domains. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. |
| 翻译后修饰 | Heavily N- and O-glycosylated. |
| 相似性 | Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains. |
| 功能 | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/test} |
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文献和实验在小鼠免疫学研究的流式细胞术实验中，准确选择抗体至关重要。面对CD45.1/CD45.2、CD90.1/CD90.2等具有品系特异性的标志物，研究人员常面临选择困惑。本文旨在系统梳理这些关键标志物的品系特异性与组织分布差异，为您提供详尽的选择指南。通过掌握这些核心要点，您将能更精准地设计流式检测方案，有效区分不同亚群，从而提升实验数据的可靠性与准确性，让小鼠流式实验设计变得更加轻松高效。 Mouse CD90.1和CD90.2 CD90又称Thy1（胸腺细胞抗原1），在小鼠中，CD90存在
-30008 CD19-APC APC-30066 Human Th1/Th2 细胞群检测 CD3-PerCP-Cy5.5 PCP55-30004 CD4-FITC FITC-30005 IFN-γ-PE PE-30053 IL4-APC APC-30043 Mouse Th1/Th2 细胞群检测 CD3-PerCP-Cy5.5 PCP55-30002 CD4-FITC FITC-30128 IFN-γ-PE PE-30074 IL4-APC APC-30026
细胞群 流式抗体搭配 货号 Human T/B/NK细胞群检测 CD45-PerCP PCP-30039 CD3-FITC FITC-30004 CD16-PE PE-30061 CD56-PE PE-30008 CD19-APC APC-30066 Human Th1/Th2 细胞群检测 CD3-PerCP-Cy5.5 PCP55-30004 CD4-FITC FITC-30005 IFN-γ-PE PE-30053 IL4-APC APC-30043
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