phospho-PAK6 (Ser560) Rabbit pAb, Cy3 conjugated(bs-3314R-Cy3)-100ul

phospho-PAK6 (Ser560) Rabbit p

Ab, Cy3 conjugated(bs-3314R-Cy3)-100ul
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  • ￥2980
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  • bs-3314R-Cy3
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-3314R-Cy3
    英文名称phospho-PAK6 (Ser560) Rabbit pAb, Cy3 conjugated
    中文名称Cy3标记的磷酸化p21激活激酶6抗体
    英文别名phospho-PAK6(Ser560); PAK4+PAK5+PAK6(phospho S474+S602+S560); CDKN1A activated kinase 6; Serine/threonine-protein kinase PAK 6; p21 activated protein kinase 6; p21 protein(Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; p21-ACTIVATED KINASE 6; p21activated kinase 6; PAK 5; PAK 6; PAK5; Serine threonine protein kinase PAK 6; Serine/threonine protein kinase PAK 6; Serine/threonine protein kinase PAK6; EC 2.7.1.37; PAK-5; PAK-6; Pak6; PAK6_HUMAN.
    产品应用ICC/IF=1:100-500, Flow-Cyt=1ug/Test, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated Synthesised phosphopeptide derived from human PAK6 around the phosphorylation site of Ser560
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases

    亚基Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.
    亚细胞定位Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
    组织特异性Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
    翻译后修饰Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.
    相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily._x000D_
    Contains 1 CRIB domain.
    功能Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

     

    应用推荐稀释比例
    {ICC/IF}{1:100-500}
    {Flow-Cyt}{1ug/Test}
    {IF}{1:100-500}

     

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