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mGluR5 Rabbit pAb, Biotin conj

ugated(bs-1247R-Bio)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-1247R-Bio
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-1247R-Bio
    英文名称mGluR5 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的促代谢型谷氨酸受体5抗体
    英文别名Glutamate receptor metabotropic 5; GPRC1E; GRM 5; GRM5; Metabotropic glutamate receptor 5; mGlu5; mGluR5a; mGluR5b; Metabotropic glutamate receptor 5 variant F; Metabotropic Glutamate Receptor 5b; Metabotropic glutamate receptor 5 variant G; Metabotropic glutamate receptor 5 variant H; PPP1R86; GRM5_HUMAN; GRM5_MOUSE.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human GRM5
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Signal transduction > G protein signaling > GPCR

    Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Glutamate Receptors

    Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR

    亚基 The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity)._x000D_
    亚细胞定位Cell Membrane
    相似性Belongs to the G-protein coupled receptor 3 family.
    功能G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteKns) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates_x000D_ a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity._x000D_
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

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