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GRK2 Rabbit pAb, Biotin conjug

ated(bs-1209R-Bio)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-1209R-Bio
  • 2026年03月27日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-1209R-Bio
    英文名称GRK2 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的G蛋白偶合受体激酶2抗体
    英文别名G-protein coupled receptor kinase 2; ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; BARK 1; BARK; BARK1; beta adrenergic receptor kinase 1; beta ARK 1; beta ARK1; G Protein Coupled Receptor Kinase 2; G protein dependent receptor kinase 2; FLJ16718; GRK 2; ARBK1_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human GRK2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Adrenergic Receptors

    Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR

    亚基Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1.
    组织特异性Expressed in peripheral blood leukocytes.
    相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
    GPRK subfamily.
    _x000D_ Contains 1 AGC-kinase C-terminal domain.
    _x000D_ Contains 1 PH domain.
    _x000D_ Contains 1 protein kinase domain.
    _x000D_ Contains 1 RGS domain.
    功能Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

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