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- Bioss
- bs-7588R-BF647
- 2025年09月30日
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100ul
| 产品编号 | bs-7588R-BF647 |
| 英文名称 | A4GALT Rabbit pAb, BF647 conjugated |
| 中文名称 | BF647标记的乳糖神经酰胺4-α-半乳糖基转移酶抗体 |
| 英文别名 | 4 N acetylglucosaminyltransferase; 4-galactosyltransferase; 4-N-acetylglucosaminyltransferase; A14GALT; A4GALT1; A4GAT_HUMAN; alpha 1 4 galactosyltransferase; alpha 1 4 N acetylglucosaminyltransferase; alpha-1; alpha-1; alpha4Gal T1; alpha4Gal-T1; CD77 synthase; GB3 synthase; Gb3S; Globotriaosylceramide synthase; Lactosylceramide 4 alpha galactosyltransferase; Lactosylceramide 4-alpha-galactosyltransferase; P blood group(P one antigen); P(k) antigen synthase; P1; P1/Pk synthase; PK; UDP galactose beta D galactosyl beta1 R 4 alpha D galactosyltransferase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase. |
| 产品应用 | Flow-Cyt=1ug/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human A4GALT/CD77 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood Cardiovascular > Blood > Blood Cell Antigens Cardiovascular > Blood > Blood Cell Antigens > RBC Antigens > Blood Group Antigens |
| 亚细胞定位 | Golgi apparatus membrane; Single-pass type II membrane protein (Probable). |
| 组织特异性 | Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta. |
| 相似性 | Belongs to the glycosyltransferase 32 family. |
| 功能 | Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis and the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive and insensitive tissues and cell lines. The highest tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, and brain. Burkitt leukemia cells express very high levels of CD77 as well as CD77 synthase, and are sensitive to verotoxin induced apoptosis. These megakaryoblasts then never mature, leading to the arrest of platelet generation in the bone marrow, which may cause thrombocytopenia, a symptom associated with various hemorrhagic conditions. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/Test} |
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A4GALT Rabbit pAb, BF647 conjugated(bs-7588R-BF647)-100ul
￥2980
