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- bs-1057R-BF405
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100ul
| 产品编号 | bs-1057R-BF405 |
| 英文名称 | Integrin Alpha 3 + Beta 1 Rabbit pAb, BF405 conjugated |
| 中文名称 | BF405标记的整合素α3β1抗体 |
| 英文别名 | Integrin alpha 3/beta 1; Integrin VLA 4 beta subunit; alpha 3 subunit of VLA 3 receptor; CD29; CD49C; Fibronectin receptor; Fibronectin receptor beta subunit; Galactoprotein B3; GAPB3; VL3A; VLA 3 alpha chain; VLA3a. |
| 中文别名 | Integrin α3β1; Integrin α3 β1; Integrin α3+β1. |
| 产品应用 | Flow-Cyt=1ug/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Integrin Alpha 3(976-1025aa) + Beta 1(35-47aa) |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Alpha |
| 亚基 | Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. |
| 翻译后修饰 | Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. |
| 相似性 | Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. |
| 功能 | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/Test} |
| {IF} | {1:100-500} |
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文献和实验5DcKyZhPRCAiEBGICEQE9nEEAjlmlbyw0EeoEtpbJt95QMPcL9MIebnA1VtD7t1YSTtXyMtDhcwzGhmZUGipbKmgJ40ebbfd9FORapFkrT5SF8FFMy26mwSZZpjsl62y1R5dfIeVuzfLdGO0Vh7UqoDlbussKp9M3R5cfLcSqUyR5Ka0y6i7ocUQGX7xnBHkJ+PBZJ/jGCIC/14EIkn+9yIW40cEIgIRgYhARGC/R+C16UHi+q1p/T3dWhUwbwuu/IF7uWjRRD
【共享】某机构发表的核酸相关研究的文章（EST,SNP等），PDF全文下载
, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin
Developing Genetically Engineered Mouse Models to Study Tumor Suppression
., Bullard, D.E., Muhlbaier, L.H., and Bigner, D.D. 1988. Specific chromosomal abnormalities in malignant human gliomas. Cancer Res. 48:405‐411. Brinster, R.L., Chen, H.Y
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