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Growth hormone receptor Rabbit

pAb, BF405 conjugated(bs-0654R-BF405)-100ul
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  • ￥2980
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  • bs-0654R-BF405
  • 2025年09月30日
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北京博奥森生物技术有限公司
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      100ul

    产品编号bs-0654R-BF405
    英文名称Growth hormone receptor Rabbit pAb, BF405 conjugated
    中文名称BF405标记的生长激素受体抗体
    英文别名GH receptor; G‌‌HBP; GHR; Growth hormone receptor precursor; Serum binding protein; Somatotropin receptor; GHR_HUMAN.
    产品应用Flow-Cyt=1μg/Test, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human GHR
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Cell Cycle > Cell differentiation

    Developmental Biology > Post embryonic development > Growth hormones

    Signal Transduction > Growth Factors/Hormones > Hormones

    亚基On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation. Interacts with ADAM17.
    亚细胞定位Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway._x000D_
    Isoform 2: Cell membrane; Single-pass type I membrane protein. Note=Remains fixed to the cell membrane and is not internalized._x000D_
    Growth hormone-binding protein: Secreted. Note=Complexed to a substantial fraction of circulating GH.
    组织特异性Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.
    翻译后修饰The soluble form (G‌‌HBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17._x000D_
    On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2._x000D_
    On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization.
    相似性Belongs to the type I cytokine receptor family. Type 1 subfamily._x000D_
    Contains 1 fibronectin type-III domain.
    功能Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway._x000D_
    The soluble form (G‌‌HBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling._x000D_
    Isoform 2 up-regulates the production of G‌‌HBP and acts as a negative inhibitor of GH signaling.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (G‌‌HBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].

     

    应用推荐稀释比例
    {Flow-Cyt}{1μg/Test}
    {IF}{1:100-500}

     

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    图标文献和实验
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    • （共享）免疫单词缩写及翻译

      -rabbit serum 羊抗兔血清 GCA gastrin cell antibody 胃泌素细胞抗体 GFAP glial fibrillary acidic protein 胶质纤维酸性蛋白 GFL green fluorescence 绿色荧光 GH growth hormone 生素激素 GLAD gold-labelled antigen detection method 金标抗原检测法 GMA glycol methacrylate

    • 【共享】某机构发表的核酸相关研究的文章（EST,SNP等），PDF全文下载

      A (2006) Polymyxin B-conjugated alpha 2-macroglobulin as an adjunctive therapy to sepsis: Modes of action and impact on lethality J Pharmacol Exp Ther 318: 762-771 Elsharawy A, Manaster C, Teuber M, Rosenstiel P, Kwiatkowski R, Huse K, Platzer M

    • Characterization of Angiotensin II Receptors

      ., Herblin, W.F., Ardecky, R.J., McCall, D.E., Carini, D.J., Duncia, J.V., Pease, L.J., Wexler, R.R., Wong, P.C., Johnson, A.L., and Timmermans, P.B.M.W.M. 1989a. Identification of angiotensin II receptor subtypes. Biochem. Biophys. Res. Commun. 165:196‐203

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