- ￥2980
- Bioss
- bs-22235R-Bio
- 2025年12月23日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
ERBB2/HER2 Rabbit pAb, PE-Cy7 conjugated(bs-0125R-PE-Cy7)-100ul
￥2980
MEF2B Rabbit pAb(bs-9470R)-50ul/100ul/200ul
￥1180phospho-CHEK2 (Ser33 + Ser35) Rabbit pAb, AP conjugated(bs-13908R-AP)-100ul
￥2980phospho-c-Jun (Thr91+Thr93) Rabbit pAb, PerCP conjugated(bs-1735R-PerCP)-100ul
￥2980
TPCN1 Rabbit pAb(bs-17163R)-50ul/100ul/200ul
￥1180
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-22235R-Bio |
| 英文名称 | Mafa Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的 v-maf 肌腱膜纤维肉瘤癌基因同源物A抗体 |
| 英文别名 | Mafa homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; Pancreatic beta-cell-specific transcriptional activator; (avian)(V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; MAFA_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Mafa |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Co-factors Epigenetics and Nuclear Signaling > Transcription > Other factors Signal Transduction > Growth Factors/Hormones > Insulin / Insulin-like |
| 亚基 | Binds DNA as a homodimer. Interacts with PCAF. Interacts with NEUROD1 and PDX1. |
| 亚细胞定位 | Nucleus. Note=Detected in nuclei of pancreas islet beta cells. |
| 组织特异性 | Selectively expressed in pancreatic beta but not in alpha cells (at protein level). Expressed in eyes and at low levels in thymus. Expressed in brain, lung, spleen and kidney. Expressed in embryo. |
| 翻译后修饰 | Ubiquitinated, leading to its degradation by the proteasome._x000D_
Phosphorylation by GSK3 requires prior phosphorylation of Ser-65 by another kinase. Phosphorylation proceeds then from Ser-61 to Thr-57, Thr-53 and Ser-49. GSK3-mediated phosphorylation increases its transcriptional activity through the recruitment of the coactivator PCAF, is required for its transforming activity and leads to its degradation through an ubiquitin/proteasome-dependent pathway. Ser-14 and Ser-65 appear to be the major phosphorylation sites. Phosphorylated by MAPK13 on serine and threonine residues (Probable). |
| 相似性 | Belongs to the bZIP family. Maf subfamily. Contains 1 bZIP (basic-leucine zipper) domain._x000D_ |
| 功能 | Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Regulates the insulin gene transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Insulin gene expression is regulated by several islet-enriched transcription factors. However, MAFA is the only beta cell-specific activator. MAFA selectively induces endogenous insulin transcription in non-beta cells. MAFA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MAFA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Mafa Rabbit pAb, Biotin conjugated(bs-22235R-Bio)-100ul
￥2980
