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- bs-0008R-APC
- 2025年12月18日
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100ul
| 产品编号 | bs-0008R-APC |
| 英文名称 | Nestin Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的巢蛋白/神经上皮干细胞蛋白抗体 |
| 英文别名 | ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_RAT; Nestin. |
| 产品应用 | Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from rat Nestin |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > Angiogenesis Cancer > Tumor biomarkers > Tumor antigens Cardiovascular > Angiogenesis > Angiogenic Factors Developmental Biology > Lineage specification > Ectoderm Neuroscience > Cell Adhesion Proteins > Cytoskeletal Proteins > Intermediate Filaments Neuroscience > Cell Type Marker > Neural Stem Cell marker Neuroscience > Neurology process > Neurogenesis Signal Transduction > Antibodies > nestin Stem Cells > Lineage Markers > Ectoderm Stem Cells > Neural Stem Cells > Intracellular Stem Cells > Neural Stem Cells > Neuron Restricted Lineage |
| 亚基 | Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3. |
| 亚细胞定位 | cytoplasm |
| 组织特异性 | CNS stem cells. |
| 翻译后修饰 | Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. |
| 相似性 | Belongs to the intermediate filament family. |
| 功能 | Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nestin is a Class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein has been widely used as a predominant marker for stem / progenitor cells, glioma cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test } |
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文献和实验Fluorochrome Absorption and Emission Spectra
light at 488 nm for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes
Fluorochrome Absorption and Emission
for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes are useful in experiments
区、1个IgC样区、1个跨膜疏水区和1个由30个氨基酸组成的胞内区。不同于其他B7家族分子的是，它具有负向调节免疫应答的作用。PD-1和PD-L1是一对共抑制分子[3]。 这对共抑制分子，对癌细胞是如何发挥作用的呢。 憋急，听我慢慢道来！ 人类身体健康的卫士「T细胞」的活化是需要接收「双重信号」的：首先，T细胞表面受体（TCR）识别由抗原提呈细胞（APCs）提呈的抗原肽，使T细胞初步活化；然后，APC表面的共刺激分子与T细胞表面的相应共刺激分子结合，使T
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