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TBLR1 Rabbit pAb, Biotin conju

gated(bs-4220R-Bio)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-4220R-Bio
  • 2025年12月03日
  • 产品信息以Bioss网站为准
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    产品编号bs-4220R-Bio
    英文名称TBLR1 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的转导素β1X连锁受体蛋白1抗体
    英文别名C21; DC42; F box like/WD repeat containing protein TBL1XR1; IRA1; nuclear receptor co-repressor/HDAC3 complex subunit; Nuclear receptor corepressor/HDAC3 complex subunit; TBL1 related protein 1; TBL1-related protein 1; TBL1XR1; Transducin(beta) like 1 X linked receptor 1; Transducin beta like 1X related protein 1; TBL1R_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human TBLR1
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins

    Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism

    亚基Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4.
    亚细胞定位Nucleus.
    组织特异性Ubiquitous.
    翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    相似性Belongs to the WD repeat EBI family.
    Contains 1 F-box-like domain.
    Contains 1 LisH domain.
    Contains 8 WD repeats.
    功能F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料TBLR1 is an F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. It plays an essential role in transcription activation mediated by nuclear receptors and probably acts as an integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of the N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

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