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phospho-FADD (Ser194) Rabbit p

Ab, AP conjugated(bs-5699R-AP)-100ul
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  • ￥2980
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  • bs-5699R-AP
  • 2025年12月03日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-5699R-AP
    英文名称phospho-FADD (Ser194) Rabbit pAb, AP conjugated
    中文名称AP标记的磷酸化Fas死亡结构域相关蛋白抗体
    英文别名FADD_HUMAN; FAS-associated death domain protein; FAS-associating death domain-containing protein; MORT1; GIG3; GIG 3; IMD90; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity;
    产品应用IHC-P=1:100-500, IHC-F=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated Synthesised phosphopeptide derived from human FADD around the phosphorylation site of Ser194
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell Death > Apoptosis > Receptors > Death receptors & ligands > FADD

    Cancer > Cell Death > Necroptosis

    Cancer > Invasion/microenvironment > Apoptosis > Death receptors & ligands > FADD

    Cell Biology > Apoptosis > Intracellular > Associated Proteins

    亚基Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8.
    组织特异性Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
    相似性Contains 1 death domain.
    _x000D_ Contains 1 DED (death effector) domain.
    功能Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}

     

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    相关实验

    • TRAF‐Mediated TNFR‐Family Signaling

      , such as TRANCE‐R and CD40, bind to TRAF6 and other TRAF proteins, activating various pathways including Src‐family kinases. IL‐1R and Toll‐like receptors are indirectly linked to TRAF6 through MyD88, Tollip, and IRAK.

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