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- bs-22860R-AP
- 2025年12月02日
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100ul
| 产品编号 | bs-22860R-AP |
| 英文名称 | Periplakin Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的周斑蛋白抗体 |
| 英文别名 | 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor; 195 kDa cornified envelope precursor protein; AW553870; KIAA0568; MGC134872; PEPL_HUMAN; Periplakin; ppl. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Periplakin |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immune System Diseases > Autoimmune Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Desmosomes |
| 亚细胞定位 | Cell junction > desmosome. Cytoplasm > cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments. |
| 组织特异性 | Expressed in stratified squamous epithelia and in some other epithelia. |
| 相似性 | Belongs to the plakin or cytolinker family. _x000D_ Contains 2 plectin repeats. _x000D_ Contains 4 spectrin repeats. |
| 功能 | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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Periplakin Rabbit pAb, AP conjugated(bs-22860R-AP)-100ul
￥2980
