Corin Rabbit pAb, BF350 conjugated(bs-7685R-BF350)-100ul

Corin Rabbit pAb, BF350 conjug

ated(bs-7685R-BF350)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-7685R-BF350
  • 2025年11月16日
  • 产品信息以Bioss网站为准
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    • 规格：

      100ul

    产品编号bs-7685R-BF350
    英文名称Corin Rabbit pAb, BF350 conjugated
    中文名称BF350标记的心脏特异性丝氨酸蛋白酶抗体
    英文别名ATC 2; ATC2; Atrial natriuteric peptide converting enzyme; Corin serine peptidase; CRN; Heart specific serine proteinase; Heart specific serine proteinase ATC2; Lrp 4; Lrp4; Pro ANP convertase; Pro ANP converting enzyme; TMPRSS 10; Transmembrane protease serine 10.
    产品应用Flow-Cyt=1ug/Test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Corin
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Blood > Blood Pressure regulation

    Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Serine protease > TMPRSS

    亚细胞定位Cell membrane; Single-pass type II membrane protein. Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10. Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage. Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.
    组织特异性Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus.
    翻译后修饰N-glycosylated; required for processing and activation.
    相似性Belongs to the peptidase S1 family.
    Contains 2 FZ (frizzled) domains.
    Contains 7 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
    Contains 1 SRCR domain.
    功能Serine-type endopeptidase involved in atrial natriuretic peptide hormone (N‌‌PPA) processing. Converts through proteolytic cleavage the non-functional propeptide N‌‌PPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-N‌‌PPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-N‌‌PPB the B-type natriuretic peptide.
    Isoform 2: has weaker endopeptidase activity compared to isoform 1._x000D_
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Corin was first described as a trypsin-like serine proteinase in the heart which processed pro-atrial natriuretic peptide into the active form ANP. Corin cleaves pro-ANP at Arg98/Ser-99, and blocking Corin message inhibits pro-ANP processing. Null mutant mice lacking Corin develop hypertension, and a series of missense mutations have been identified in humans with high blood pressure and hypertension. Corin is a member of the type-II transmembrane serine proteinases, such as Hepsin, Epitheliasin, Matriptase and enteropeptidase. The Corin domain structure includes a cytoplasmic domain, a transmembrane domain, a spacer region, a frizzled-like domain, 5 LDL Receptor-like domains, another frizzled-like domain, 3 more LDLR-like repeats, a SRCR (Scavenger Receptor-Cysteine Rich) domain (also called macrophage scavenger-like domain), and finally the trypsin-like serine proteinase domain. The complex domain structure puts Corin into the “mosaic” TMPRSS family, so named because of the wide variety of domains.

     

    应用推荐稀释比例
    {Flow-Cyt}{1ug/Test}

     

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