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- Bioss
- bs-2525R-Bio
- 2025年11月21日
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100ul
| 产品编号 | bs-2525R-Bio |
| 英文名称 | CD155 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的脊髓灰质炎病毒受体抗体 |
| 英文别名 | Poliovirus receptor; poliovirus receptor isoform alpha; CD155; FLJ25946; HVED; Necl-5; NECL5; PVS; TAGE4; Taa1; CD155 antigen; Nectin like 5; Nectin like protein 5; Ortholog of mouse Tage4; PVR; PVR_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD155 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚基 | Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT. |
| 亚细胞定位 | Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cell membrane; Single-pass type I membrane protein. Isoform Beta: Secreted. Isoform Gamma: Secreted. |
| 翻译后修饰 | N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4. |
| 相似性 | Belongs to the nectin family._x000D_
Contains 2 Ig-like C2-type (immunoglobulin-like) domains._x000D_ Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验- or triple-labeling immunofluorescence, it is necessary to use primary antibodies raised in different host species such as mouse, rabbit, and goat. However, in many cases, suitable primary antibodies raised in different species are unavailable
【共享】Present and future applications of gold in rapid assays
by hydrophobic binding. For proteins with a high content of such amino acids (e.g., immunoglobulins), this is an important component of total binding, which explains why prolonged exposure of conjugated particles to detergent containing buffers will result
complexes of CD22 revealed by in situ photoaffinity protein‐glycan crosslinking. Nat. Chem. Biol. 1:93‐97. Hang, H.C. and Bertozzi, C.R. 2001. Ketone isosteres of 2‐N
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