Blank control: PANC1.
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Primary Antibody (green line): Rabbit Anti-MRP1 antibody (bs-0657R-FITC)
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Dilution: 2μg /10^6 cells;
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Isotype Control Antibody (orange line): Rabbit IgG .
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Protocol
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The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. Acquisition of 20,000 events was performed._x000D_
- ￥2980
- Bioss
- bs-0657R-FITC
- 2025年11月11日
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产品信息以Bioss网站为准
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100ul
| 产品编号 | bs-0657R-FITC |
| 英文名称 | MRP1/ABCC1 Rabbit pAb, FITC conjugated |
| 中文名称 | FITC标记的多药耐药相关蛋白1抗体 |
| 英文别名 | Multidrug Resistanec-Associated Protein 1; ABC 29; ABC29; ABCC 1; ABCC; ABCC1; ATP binding cassette sub family C(CFTR/MRP) member 1; ATP binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C(4) transporter; LTC4 transporter; MRP 1; MRP; Multidrug resistance associated protein 1; Multidrug resistance protein; Multiple drug resistance associated protein; Multiple drug resistance protein 1; MRP1_HUMAN. |
| 产品应用 | Flow-Cyt=2ug/test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MRP1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Cancer > Drug resistance > MRP-related proteins Cardiovascular > Atherosclerosis > Hypertension > Sodium/ion transport Cardiovascular > Blood > Blood Pressure regulation Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Metabolism > Pathways and Processes > Metabolic signaling pathways > Drug metabolism Metabolism > Types of disease > Heart disease Signal Transduction > Metabolism > Drug metabolism Signal Transduction > Metabolism > Plasma Membrane > Channels |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Lung, testis and peripheral blood mononuclear cells. |
| 相似性 | Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. |
| 功能 | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {2ug/test} |
| {IF} | {1:100-500} |
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MRP1/ABCC1 Rabbit pAb, FITC conjugated(bs-0657R-FITC)-100ul
￥2980
