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- Bioss
- bs-19671R-AP
- 2025年11月05日
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100ul
| 产品编号 | bs-19671R-AP |
| 英文名称 | PREX1 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的PREX1蛋白抗体 |
| 英文别名 | 5)-dependent Rac exchanger 1; KIAA1415; OTTHUMP00000031228; P REX1; P Rex1 protein like; P-Rex1; Phosphatidylinositol 3, 4, 5 trisphosphate dependent Rac exchange factor 1; Phosphatidylinositol 3, 4, 5 trisphosphate dependent Rac exchanger 1; Phosphatidylinositol 3, 4, 5 trisphosphate dependent Rac exchanger 1 protein; Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 1 protein; Prex1; PREX1_HUMAN; PtdIns(3; PtdIns(3, 4, 5) dependent Rac exchanger 1; SET domain containing 6; Setd6 |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PREX1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies Signal Transduction > Second Messenger > Nucleotide Messenger > GTP |
| 亚细胞定位 | Cytoplasm > cytosol. Cell membrane. Mainly cytosolic. Some amount is apparently associated to the plasma membrane. |
| 组织特异性 | Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
| 相似性 | Contains 1 DEP domain. _x000D_ Contains 1 DH (DBL-homology) domain. _x000D_ Contains 1 PDZ (DHR) domain. _x000D_ Contains 2 PH domains. |
| 功能 | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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PREX1 Rabbit pAb, AP conjugated(bs-19671R-AP)-100ul
￥2980
