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- bs-5753P
- 2025年10月15日
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500ug
| 产品编号 | bs-5753P |
| 英文名称 | phospho-CENPU (Thr78) Antibody Blocking Peptide |
| 中文名称 | 磷酸化卡波西氏肉瘤疱疹病毒潜伏核抗原相互作用蛋白1封闭多肽 |
| 英文别名 | MLF1 Interacting Protein/PBIP1(phospho T78); MLF1 Interacting Protein/PBIP1 (phospho T78);MLF1 Interacting Protein (phospho T78); MLF1 Interacting Protein (phospho Thr78); p-MLF1 Interacting Protein (Thr78); CENP U; CENP50; CENPU; centromere protein U; HHV8 LNAIP1; ICEN24; Kaposi Sarcoma Herpesvirus latent nuclear antigen interacting protein 1; KLIP-1; KLIP1; KSHV latent nuclear antigen interacting protein 1; KSHV LNAIP1; LNAIP 1; LNAIP-1; MLF1IP1; PBIP1; CENPU_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell cycle > Kinases/phosphatases Cell Biology > Cell Cycle > Kinases/Phosphatases Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚基 | Interacts with MLF1IP. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53. |
| 亚细胞定位 | Cytoplasm. Nucleus. In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM. |
| 组织特异性 | Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes. |
| 翻译后修饰 | Phosphorylation is required for binding to YWHAZ (By similarity). |
| 相似性 | Belongs to the MLF family. |
| 功能 | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
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文献和实验简介】 N-连接的糖基化是一种具有重要生物学意义的翻译后修饰过程，但是现在已经发现的糖基化蛋白并不多。作者在这里采取了一种”滤纸收集样品（filter aided sample preparation,FASP）“的方法，籍此糖基化多肽可以富集于载有凝集素的滤纸上，然后用高精确度的质谱技术从小鼠的四种组织和血浆的2352种蛋白质上发现6367个糖基化位点。其中，涵盖了Swiss-port服务器中已经试验验证的830个糖基化位点中的74%，而另外5753个糖基化位点则是第一次被发现。 这些位点都带有” N
N-连接的糖基化是一种具有重要生物学意义的翻译后修饰过程，但是现在已经发现的糖基化蛋白并不多。作者在这里采取了一种“滤纸收集样品（filter aided sample preparation,FASP）”的方法，籍此糖基化多肽可以富集于载有凝集素的滤纸上，然后用高精确度的质谱技术从小鼠的四种组织和血浆的2352种蛋白质上发现6367个糖基化位点。其中，涵盖了Swiss-port服务器中已经试验验证的830个糖基化位点中的74%，而另外5753个糖基化位点则是第一次被发现
deposit: NoPrice_code: AAvailability in cell line catalogues: ATCC CCL 61; IZSBS BS CL15; DSMZ ACC 110;Bibliographic references:J Exp Med 1958;108:945 Proc Nat Acad Sci USA 1968;60:1275CHO-K1 (hamster, Chinese, ovary)Morphology: epithelial-likeSpecies
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