- ￥2800
- Proteintech
- CL647-67589
- 2025年10月09日
- IF/ICC, FC (Intra)
- Mouse
- Human, mouse, rat, pig
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human Drebrin protein
- 亚型：
IgG2a
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
CoraLite® Plus 647 Fluorescent Dye
- 适应物种：
Human, mouse, rat, pig
- 宿主：
Mouse
- 应用范围：
IF/ICC, FC (Intra)
- 靶点：
Drebrin
- 抗体英文名：
CoraLite® Plus 647-conjugated Drebrin Monoclonal antibody
- 抗体名：
CoraLite® Plus 647-conjugated Drebrin Monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive IF/ICC detected in | SH-SY5Y cells |
| Positive FC (Intra) detected in | SH-SY5Y cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL647-67589 targets Drebrin in IF/ICC, FC (Intra) applications and shows reactivity with Human, mouse, rat, pig samples.
| 经测试应用 | IF/ICC, FC (Intra) |
| 经测试反应性 | Human, mouse, rat, pig |
| 免疫原 |
CatNo: Ag22635 Product name: Recombinant human Drebrin protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-353 aa of BC007567 Sequence: MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIE |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | drebrin 1 |
| 别名 | DBN1, drebrin 1, Developmentally-regulated brain protein, DBN 1, 1A12H1 |
| 观测分子量 | 110-120 kDa |
| GenBank蛋白编号 | BC007567 |
| 基因名称 | Drebrin |
| Gene ID (NCBI) | 1627 |
| ENSEMBL Gene ID | ENSG00000113758 |
| RRID | AB_3084824 |
| 偶联类型 | CoraLite® Plus 647 Fluorescent Dye |
| 最大激发/发射波长 | 654 nm / 674 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q16643 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Drebrin (DBN1) is an actin binding and stabilizing protein with roles in endocytosis, formation of dendrite spines in neurons and coordinating cell-cell synapses in immune cells. Preferentially expressed in the brain, it is highly localized in dendritic spines and regulates spine shapes. It has two isoforms that are splice variants, with drebrin A being expressed in neural cells, and drebrin E is present in several other cell types. Recently it has been reported that circulating DBN1 levels correlated with retinal nerve fiber layer defect and may reflect the severity of retinal ganglion cells injury in glaucoma patients.
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