- ￥2800
- Proteintech
- CL488-66938
- 2025年10月09日
- WB
- Mouse
- human, mouse, pig
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human ZFP36 protein
- 亚型：
IgG2a
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
CoraLite® Plus 488 Fluorescent Dye
- 适应物种：
human, mouse, pig
- 宿主：
Mouse
- 应用范围：
WB
- 靶点：
ZFP36
- 抗体英文名：
CoraLite® Plus 488-conjugated ZFP36 Monoclonal antibody
- 抗体名：
CoraLite® Plus 488-conjugated ZFP36 Monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive WB detected in | NCI-H1299 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL488-66938 targets ZFP36 in WB applications and shows reactivity with human, mouse, pig samples.
| 经测试应用 | WB |
| 经测试反应性 | human, mouse, pig |
| 免疫原 |
CatNo: Ag28473 Product name: Recombinant human ZFP36 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-326 aa of BC009693 Sequence: MDLTAIYESLLSLSPDVPVPSDHGGTESSPGWGSSGPWSLSPSDSSPSGVTSRLPGRSTSLVEGRSCGWVPPPPGFAPLAPRLGPELSPSPTSPTATSTTPSRYKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLAAPGHPPVLRQSISFSGLPSGRRTSPPPPGLAGPSLSSSSFSPSSSPPPPGDLPLSPSAFSAAPGTPLARRDPTPVCCPSCRRATPISVWGPLGGLVRTPSVQSLGSDPDEYASSGSSLGGSDSPVFEAGVFAPPQPVAAPRRLPIFNRISVSE |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | zinc finger protein 36, C3H type, homolog (mouse) |
| 别名 | TTP, 1A5E6, Growth factor-inducible nuclear protein NUP475, mRNA decay activator protein ZFP36, Tristetraprolin |
| 计算分子量 | 326 aa, 34 kDa |
| 观测分子量 | 34 kDa |
| GenBank蛋白编号 | BC009693 |
| 基因名称 | ZFP36 |
| Gene ID (NCBI) | 7538 |
| 偶联类型 | CoraLite® Plus 488 Fluorescent Dye |
| 最大激发/发射波长 | 493 nm / 522 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P26651 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The expression of many cytokines is regulated post-transcriptionally by factors that modulate mRNA transport, translation, and stability. Much of this regulation occurs by the binding and stabilizing, or destabilizing, of cytokine mRNAs by proteins that recognize adenosine and uridine-rich elements (AREs) in untranslated regions of target transcripts. Zfp36 is a mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. It was demonstrated to physically interact with the p65 subunit of nuclear factor-κB leading to decreased nuclear import and diminished transcriptional activation mediated by nuclear factor-κB. It acted by specifically binding ARE-containing mRNAs and promoting their degradation, and has a crucial role in the post-transcriptional regulation of tumor necrosis factor (TNF).
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