- ￥1000 - 2490
- Proteintech
- CL647-65181
- 2025年10月09日
- FC
- Mouse
- human, mouse, rabbit, canine
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- 详细信息
- 技术资料
- 亚型：
IgG1, kappa
- 保存条件：
Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
CoraLite® Plus 647 Fluorescent Dye
- 适应物种：
human, mouse, rabbit, canine
- 宿主：
Mouse
- 应用范围：
FC
- 靶点：
CD146/MCAM
- 抗体英文名：
CoraLite® Plus 647 Anti-Human CD146/MCAM (P1H12)
- 抗体名：
CoraLite® Plus 647 Anti-Human CD146/MCAM (P1H12)
- 规格：
25tests/100tests
| 规格： | 25tests | 产品价格： | ￥1000.0 |
|---|---|---|---|
| 规格： | 100tests | 产品价格： | ￥2490.0 |
经过测试的应用
| Positive FC detected in | A375 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : 5 ul per 10^6 cells in 100 μl suspension |
| This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL647-65181 targets CD146/MCAM in FC applications and shows reactivity with human, mouse, rabbit, canine samples.
| 经测试应用 | FC |
| 经测试反应性 | human, mouse, rabbit, canine |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Mouse / IgG1, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | melanoma cell adhesion molecule |
| 别名 | CD146, MCAM, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, MUC18 |
| 计算分子量 | 646 aa, 72 kDa |
| GenBank蛋白编号 | BC056418 |
| 基因名称 | CD146 |
| Gene ID (NCBI) | 4162 |
| RRID | AB_3084807 |
| 偶联类型 | CoraLite® Plus 647 Fluorescent Dye |
| 最大激发/发射波长 | 654 nm / 674 nm |
| 形式 | Liquid |
| 纯化方式 | Affinity purification |
| UNIPROT ID | P43121 |
| 储存缓冲液 | PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. |
| 储存条件 | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein of 113-130 kDa, belonging to the immunoglobulin (Ig) superfamily (PMID: 8378324; 25993332). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) (PMID: 19356677). In addition to the membrane-anchored form of CD146, a soluble form of CD146 (sCD146, 105 kDa) has also been found in human plasma and in the supernatant of cultured human endothelial cells (PMID: 9462829; 19229070; 16374253; 14597988).
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