- ￥2800
- Proteintech
- CL555-80137
- 2026年05月29日
- IF/ICC
- Rabbit
- Human, Mouse, rat
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- 详细信息
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- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Recombinant
- 标记物：
CoraLite®555 Fluorescent Dye
- 适应物种：
Human, Mouse, rat
- 宿主：
Rabbit
- 应用范围：
IF/ICC
- 靶点：
MAP2K3
- 抗体英文名：
CoraLite®555-conjugated MAP2K3 Recombinant monoclonal antibody
- 抗体名：
CoraLite®555-conjugated MAP2K3 Recombinant monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive IF/ICC detected in | HeLa cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL555-80137 targets MAP2K3 in IF/ICC applications and shows reactivity with Human, Mouse, rat samples.
| 经测试应用 | IF/ICC |
| 经测试反应性 | Human, Mouse, rat |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | mitogen-activated protein kinase kinase 3 |
| 别名 | MAP kinase kinase 3, MAP2K3, MAPK/ERK kinase 3, MAPKK 3, MAPKK3, MEK 3, MEK3, MKK3, PRKMK3 |
| 计算分子量 | 347 aa, 39 kDa |
| 观测分子量 | 39 kDa |
| GenBank蛋白编号 | BC032478 |
| 基因名称 | MAP2K3 |
| Gene ID (NCBI) | 5606 |
| RRID | AB_2919708 |
| 偶联类型 | CoraLite®555 Fluorescent Dye |
| 最大激发/发射波长 | 557 nm / 570nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P46734 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
MAP2K3, also named as MKK3, is a member of dual specificity kinase group and serves as a specific activator of p38 MAPK with MKK6. MKK3 can be phosphorylated by cytokines and environmental stress at sites Ser189 and Thr193 by MKKK proteins (MEKK 1-4). MKK3 plays a key role in cell differentiation, motility, division and death. It has been reported that MKK3 targeting may represent an effective and potentially safe therapeutic strategy to selectively kill cancer cells in colorectal cancer patients. (PMID: 31695024, 30770795, 26805700, 8622669)
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