- ￥1500 - 3280
- Proteintech
- 84563-1-RR
- 2025年10月09日
- WB, ELISA
- Rabbit
- human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Rabbit
- 应用范围：
WB, ELISA
- 靶点：
Phospho-SH3PXD2B (Ser291)
- 抗体英文名：
Phospho-SH3PXD2B (Ser291) Recombinant monoclonal antibody
- 抗体名：
Phospho-SH3PXD2B (Ser291) Recombinant monoclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2480.0 |
| 规格： | 150ul | 产品价格： | ￥3280.0 |
经过测试的应用
| Positive WB detected in | HeLa cells, λ phosphatase treated HeLa cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:4000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
84563-1-RR targets Phospho-SH3PXD2B (Ser291) in WB, ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, ELISA |
| 经测试反应性 | human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | SH3 and PX domains 2B |
| 别名 | Phospho-SH3PXD2B, Phospho-SH3PXD2B Ser291, P-SH3PXD2B, P-SH3PXD2B (Ser291), SH3PXD2B (Ser291) |
| 计算分子量 | 911aa, 102 kDa |
| 观测分子量 | 120 kDa |
| GenBank蛋白编号 | NM_001017995 |
| 基因名称 | SH3PXD2B |
| Gene ID (NCBI) | 285590 |
| RRID | AB_3672071 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | A1X283 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
SH3 and PX domains 2B (SH3PXD2B) is also known as tyrosine kinase substrate with four SH3 domains (Tks4). It consists of the N-terminal phox homology domain, four Sr homology 3 domains, several proline-rich regions, and Src phosphorylation sites. Previous studies have shown that SH3PXD2B is an essential invadopodium scaffold protein and can stimulate actin polymerization, recruit membrane type-1 matrix metalloproteinase (MT1-MMP) to intracellular membranes, and increase Nox1-dependent reactive oxygen species (ROS) production. (PMID: 33906640)
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文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
the phosphorylation site; therefore, substrate?directed, phosphorylation?state?sensitive, motif?specific (?phospho?motif?) antibodies represent powerful tools to identify novel kinase substrates and to investigate mechanisms of substrate phosphorylation
), and causes activation of KOR. Agonist-activated KOR becomes a substrate for G protein receptor kinase (GRK), which phosphorylates the Ser369 residue at the C-terminal tail of the receptor in the first step in the β-Arrestin-dependent desensitization cascade
XBB.1.5 毒株的传播力为何这么强？北大曹云龙团队最新研究揭示相关机制
导读 SARS-CoV-2 变体 BQ.1.1 和 XBB.1 已在全球范围内传播，前期的研究数据表明，这两个变体与大多数 Omicron 突变体相比具有更优越的生长优势。但是，根据最新的消息，另一 SARS-CoV-2 重组亚型 XBB.1.5 在美国感染人数快速增长，已迅速成为美国的优势毒株，预计很快将会超过现有的流行亚型，并且极有可能引发下一波全球 COVID-19 传播。 图片来源：bioRxiv 尽管 XBB.1.5 拥有着高传播性，但是其内在的分子机制目前仍不清楚。2023 年
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