- ￥5800
- Proteintech
- 17049-1-PBS
- 2025年10月09日
- WB, IHC, IF/ICC, ELISA
- Rabbit
- human, mouse
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human LATS1 protein
- 亚型：
IgG
- 保存条件：
Store at -80°C.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse
- 宿主：
Rabbit
- 应用范围：
WB, IHC, IF/ICC, ELISA
- 靶点：
LATS1
- 抗体英文名：
LATS1 Polyclonal antibody, PBS Only
- 抗体名：
LATS1 Polyclonal antibody, PBS Only
- 规格：
100ug
产品信息
17049-1-PBS targets LATS1 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, IHC, IF/ICC, ELISA |
| 经测试反应性 | human, mouse |
| 免疫原 |
CatNo: Ag10709 Product name: Recombinant human LATS1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-135 aa of BC015665 Sequence: MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEEDHLSVACSPISLTKPFLI |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | LATS, large tumor suppressor, homolog 1 (Drosophila) |
| 别名 | WARTS, Serine/threonine-protein kinase LATS1, LATS 1, h-warts, EC:2.7.11.1 |
| 计算分子量 | 15 kDa, 127 kDa |
| 观测分子量 | 140-150 kDa, 120 kDa |
| GenBank蛋白编号 | BC015665 |
| 基因名称 | LATS1 |
| Gene ID (NCBI) | 9113 |
| RRID | AB_2281011 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O95835 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
LATS1(Large tumor suppressor homolog 1) is also named as WARTS and belongs to the AGC Ser/Thr protein kinase family. The gene encodes a highly conserved (from fly to human) protein kinase that plays a crucial role in the prevention of tumor formation by controlling the progression of mitosis. The expression of both long(170 kDa) and short lats1 isoforms(120 kDa) in vertebrate retinal cells raises the possibility that these lats1 proteins may act as negative key regulators of the cell cycle each of them performing a unique role (PMID:15777619). In mammalian cells, LATS1 was phosphorylated in a cell cycle-dependent manner and complexed with CDC2 in early mitosis (PMID:9988268). LATS1 also can be detected as 120 kDa and 140-150 kDa, and play a key role in the regulation of Hippo pathway (PMID: 27940445).
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