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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant human IL-13RA1 protein
- 亚型:
IgG
- 保存条件:
Store at -20°C. Stable for one year after shipment.
- 克隆性:
Polyclonal
- 标记物:
Unconjugated
- 适应物种:
human, mouse
- 宿主:
Rabbit
- 应用范围:
WB, ELISA
- 靶点:
IL-13Ra1/CD213a1
- 抗体英文名:
IL-13Ra1/CD213a1 Polyclonal antibody
- 抗体名:
IL-13Ra1/CD213a1 Polyclonal antibody
- 规格:
50ul/100ul/150ul
| 规格: | 50ul | 产品价格: | ¥1350.0 |
|---|---|---|---|
| 规格: | 100ul | 产品价格: | ¥2200.0 |
| 规格: | 150ul | 产品价格: | ¥3000.0 |
经过测试的应用
| Positive WB detected in | HT-29 cells, Jurkat cells, Raji cells, mouse skeletal muscle tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:3000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
27916-1-AP targets IL-13Ra1/CD213a1 in WB, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, ELISA |
| 经测试反应性 | human, mouse |
| 免疫原 |
CatNo: Ag25542 Product name: Recombinant human IL-13RA1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-277 aa of BC009960 Sequence: MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYV |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | interleukin 13 receptor, alpha 1 |
| 别名 | IL13RA1, Cancer/testis antigen 19, CD213A1, CT19, IL 13 receptor subunit alpha 1 |
| 计算分子量 | 49 kDa |
| 观测分子量 | 70 kDa |
| GenBank蛋白编号 | BC009960 |
| 基因名称 | IL-13Rα1 |
| Gene ID (NCBI) | 3597 |
| RRID | AB_3086010 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P78552 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
IL-13 is an immunoregulatory cytokine secreted predominantly by activated T-helper 2 (Th2) cells and performs multiple functions through a complex receptor system comprised of IL-4Rα and two IL-13 binding proteins, IL-13Rα1 and IL-13Rα2 (PMID: 12704343). IL-13Rα1 is a 65- to 70-kd glycosylated transmembrane protein (PMID: 10856136; 9723655). IL-13Rα1 is expressed on a wide range of cells including B cells, monocytes, macrophages, basophils, mast cells, and endothelial cells (PMID: 10856136; 31866859). IL-13 binding to the IL-4Rα/IL-13Rα1 complex leads to activation of JAK1, JAK2, and TYK2 and subsequent phosphorylation of STAT6 and STAT3 (PMID: 31866859).
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文献和实验。它包括APC摄取抗原加工成多肽分子,MHCⅠ或MHCⅡ灯分子将抗原信息分别呈递给CD8或CD4细胞,激活特异性T细胞反应等一系列过程。该过程又分为MHCⅠ和MHCⅡ类分子限制性抗原呈递两条途径[4]。 1.MHCⅠ类分子限制性抗原呈递:MHCⅠ类分子限制的抗原加工和呈递是与胞生物合成MHCⅠ分子的转运相关联的。多数有核细胞都转录并表达MHCⅠ类基因,并预定方式将MHCⅠ类分子的重链和轻链(β2微球蛋白)转运入内质网腔。内源性和外源性蛋白经细胞质中蛋白酶降解形成的短多肽,被位于内质
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
1, mRNA 8138 NM_004689 Homo sapiens metastasis associated 1 (MTA1), mRNA 506 NM_001848 Homo sapiens collagen, type VI, alpha 1 (COL6A1), mRNA 757 NM_004068 Homo sapiens adaptor-related protein complex 2, mu 1 subunit (AP2M1), mRNA 2188 NM
p70(IL-12 p70) ELISA 48T/96T 1000/1800 进口分装 F01410 白介素 -12 受体 (IL-12R) ELISA 48T/96T 1500/2500 进口分装 F01420 白介素 -13(IL-13) ELISA 48T/96T 1500/2500 进口分装 F01430 白介素 -15(IL-15) ELISA 48T/96T 1500/2500 进口分装 F01440 白介素 -16(IL-16) ELISA 48T/96
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