- ￥5800
- Proteintech
- 66922-2-PBS
- 2026年05月28日
- WB, IHC, IF/ICC, ELISA
- Mouse
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human Integrin beta-4 protein
- 亚型：
IgG1
- 保存条件：
Store at -80°C.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Mouse
- 应用范围：
WB, IHC, IF/ICC, ELISA
- 靶点：
Integrin Beta 4
- 抗体英文名：
Integrin Beta 4 Monoclonal antibody, PBS Only
- 抗体名：
Integrin Beta 4 Monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
66922-2-PBS targets Integrin Beta 4 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, IHC, IF/ICC, ELISA |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag17395 Product name: Recombinant human Integrin beta-4 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 27-354 aa of BC126411 Sequence: ANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSN |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | integrin, beta 4 |
| 别名 | ITGB4, 1C2A11, CD104, GP150, Integrin beta-4 |
| 计算分子量 | 1752 aa, 195 kDa |
| 观测分子量 | 200-210 kDa |
| GenBank蛋白编号 | BC126411 |
| 基因名称 | Integrin beta 4 |
| Gene ID (NCBI) | 3691 |
| RRID | AB_2882249 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P16144 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-4 is predominantly expressed in squamous epithelial cells, endothelial cells, immature thymocytes, Schwann cells, and fibroblasts of the peripheral nervous system (PMID: 28084395). Integrin beta-4 pairs with alpha-6, and the heterodimeric integrin alpha-6/beta-4 is a receptor for laminin. Integrin alpha-6/beta-4 plays a critical structural role in the hemidesmosome of epithelial cells, and also plays a role in the invasive and metastatic phenotype of various cancers.
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文献和实验-Dilke KM et al, Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Investig. 103:229-238
. and Kunapuli, S.P. (2002). Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors . Blood 99(1): 193-8. Khetawat, G., Faraday, N
Jin, J., Quinton, T.M., Zhang, J., Rittenhouse, S.E. and Kunapuli, S.P. (2002). Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors
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