- ￥2800
- Proteintech
- CL488-82791
- 2025年10月09日
- IF/ICC
- Rabbit
- human, rat
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human UPF1 protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Recombinant
- 标记物：
CoraLite® Plus 488 Fluorescent Dye
- 适应物种：
human, rat
- 宿主：
Rabbit
- 应用范围：
IF/ICC
- 靶点：
UPF1
- 抗体英文名：
CoraLite® Plus 488-conjugated UPF1 Recombinant monoclonal antibody
- 抗体名：
CoraLite® Plus 488-conjugated UPF1 Recombinant monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive IF/ICC detected in | HepG2 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL488-82791 targets UPF1 in IF/ICC applications and shows reactivity with human, rat samples.
| 经测试应用 | IF/ICC |
| 经测试反应性 | human, rat |
| 免疫原 |
CatNo: Ag29057 Product name: Recombinant human UPF1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 310-607 aa of BC039817 Sequence: VKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELL |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | UPF1 regulator of nonsense transcripts homolog (yeast) |
| 别名 | RENT1, 3O15, ATP-dependent helicase RENT1, EC:3.6.4.12, KIAA0221 |
| 计算分子量 | 123 kDa |
| 观测分子量 | 123-130 kDa |
| GenBank蛋白编号 | BC039817 |
| 基因名称 | UPF1 |
| Gene ID (NCBI) | 5976 |
| RRID | AB_3673078 |
| 偶联类型 | CoraLite® Plus 488 Fluorescent Dye |
| 最大激发/发射波长 | 493 nm / 522 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q92900 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Up-Frameshift Suppressor 1 Homolog (UPF1) is the central factor in nonsense-mediated mRNA decay (NMD) and is also directly involved in telomere homeostasis, DNA replication, histone mRNA degradation and staufen-mediated mRNA decay (PMID: 29382845). It is a potential modulator of MALAT1 and that UPF1/MALAT1 pathway could be a therapeutic target for gastric cancer (PMID: 28942451). The molecular mass of UPF1 is 123-130 kDa.
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