- ￥5800
- Proteintech
- 85804-1-PBS
- 2025年10月09日
- WB, Indirect ELISA
- Rabbit
- human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -80°C.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 宿主：
Rabbit
- 应用范围：
WB, Indirect ELISA
- 靶点：
Phospho-Myosin Light Chain 2 (Thr18/Ser19)
- 抗体英文名：
Phospho-Myosin Light Chain 2 (Thr18/Ser19) Recombinant monoclonal antibody, PBS Only
- 抗体名：
Phospho-Myosin Light Chain 2 (Thr18/Ser19) Recombinant monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
85804-1-PBS targets Phospho-Myosin Light Chain 2 (Thr18/Ser19) in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | myosin, light chain 12A, regulatory, non-sarcomeric |
| 别名 | MYL12B, MYL9, P MYL12A, P MYL12B, P Myosin Light Chain 2 (Thr18/Ser19) |
| 计算分子量 | 171 aa, 20 kDa |
| 观测分子量 | 19-20 kDa |
| GenBank蛋白编号 | BC016372 |
| 基因名称 | MYL12A |
| Gene ID (NCBI) | 10627 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P19105 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Myosin II is an actin-binding protein composed of MHC (myosin heavy chain), MLCs/MRLCs (myosin regulatory light chains) and ELCs (essential light chains). The Myosin Light Chains are divided into basic MLC (MLC I) and regulatory MLC (MLC II or Myosin Regulatory Light Chain, MRLC). MRLC can be classified into two major types: : class I MRLC found in muscles (MLC1, MLC2, MLC3, MYL4, MYL5, MYL6, MYL7, etc), and class II MRLCs present in non-muscle cells (such as MYL9, MYL12A, MYL12B). Phosphorylation of myosin II regulatory light chain (MRLC) is important for cell motility and cytokinesis in nonmuscle cells. Phosphorylation of MRLC at Ser19 (1P-MRLC) enhances myosin II activity, which is further enhanced by MRLC diphosphorylation at Thr18/Ser19 (2P-MRLC) in vitro .PMID: 23951055,PMID: 21126233
This antibody can recognize the phosphorylation of three highly homologous Myosin-regulated light chains: MYL12A, MYL12B and MYL9.
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