- ￥5800
- Proteintech
- 67121-1-PBS
- 2025年10月09日
- WB, IHC, IF/ICC, Indirect ELISA
- Mouse
- human, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human PIK3CB protein
- 亚型：
IgG1
- 保存条件：
Store at -80°C.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human, rat
- 宿主：
Mouse
- 应用范围：
WB, IHC, IF/ICC, Indirect ELISA
- 靶点：
PI3 Kinase p110 Beta
- 抗体英文名：
PI3 Kinase p110 Beta Monoclonal antibody, PBS Only
- 抗体名：
PI3 Kinase p110 Beta Monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
67121-1-PBS targets PI3 Kinase p110 Beta in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, rat samples.
| 经测试应用 | WB, IHC, IF/ICC, Indirect ELISA |
| 经测试反应性 | human, rat |
| 免疫原 |
CatNo: Ag17505 Product name: Recombinant human PIK3CB protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 139-373 aa of BC114432 Sequence: SLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEV |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | phosphoinositide-3-kinase, catalytic, beta polypeptide |
| 别名 | PI3K p110(beta), PIK3CB, PI3K, PI3 kinase subunit beta, p110 BETA |
| 计算分子量 | 1070 aa, 123 kDa |
| 观测分子量 | 120-130 kDa |
| GenBank蛋白编号 | BC114432 |
| 基因名称 | PI3 Kinase p110 Beta |
| Gene ID (NCBI) | 5291 |
| RRID | AB_2882424 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P42338 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PIK3CB(phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform) is also named as PIK3C1, PI3K-beta, p110beta. The gene encodes a 1070 amino acid protein which belongs to the PI3/PI4-kinase family. Phosphoinositide 3-kinases (PI3Ks) have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. The class I PI3 kinases are heterodimers composed of 110 kDa catalytic subunits that associate with regulatory adaptor proteins. Four class I catalytic subunits have been identified, PIK3CA (p110α), PIK3CB (p110β), PIK3CD (p110δ) and PIK3CG (p110γ)(PMID:19177002).
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文献和实验tyrosine kinases (RTKs) and the concomitant assembly of receptor–PI3K complexes. These complexes localize at the membrane where the p110 subunit of PI3K catalyses the conversion of PtdIns(4,5)P2 (PIP2) to PtdIns(3,4,5)P3 (PIP3). PIP3 serves as a second
synthase kinase 3beta as a target for the therapy of shock and inflammation. Shock. 27 , 113–123. 8. Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P. (1996) Binding of GSK3beta to the APC-beta-catenin complex
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
occurs downstream of growth factor and phosphatidylinositol3 kinase (PI3K) signalling. Activation of the canonicalWnt pathway also inhibits GSK3 activity, although this is notmediated by N-terminal phosphorylation but by protein–proteininteractions (9 –
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