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- 文献和实验
- 技术资料
- 亚型:
IgG1, kappa
- 保存条件:
Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性:
Monoclonal
- 标记物:
Cardinal Red™ Fluorescent Dye
- 适应物种:
Human
- 宿主:
Mouse
- 应用范围:
FC
- 靶点:
CD31
- 抗体英文名:
Cardinal Red™ Anti-Human CD31 (WM-59)
- 抗体名:
Cardinal Red™ Anti-Human CD31 (WM-59)
- 规格:
25tests/100tests
| 规格: | 25tests | 产品价格: | ¥920.0 |
|---|---|---|---|
| 规格: | 100tests | 产品价格: | ¥2310.0 |
经过测试的应用
| Positive FC detected in | human PBMCs |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : 5 ul per 10^6 cells in 100 μl suspension |
| This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CR-65268 targets CD31 in FC applications and shows reactivity with Human samples.
| 经测试应用 | FC |
| 经测试反应性 | Human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Mouse / IgG1, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | platelet/endothelial cell adhesion molecule |
| 别名 | CD31, EndoCAM, FLJ58394, GPIIA, PECA1, PECAM 1, PECAM1, VEC marker |
| 计算分子量 | 83 kDa |
| GenBank蛋白编号 | BC022512 |
| 基因名称 | CD31 |
| Gene ID (NCBI) | 5175 |
| ENSEMBL Gene ID | ENSG00000261371 |
| RRID | AB_3084989 |
| 偶联类型 | Cardinal Red™ Fluorescent Dye |
| 最大激发/发射波长 | 592 nm / 611 nm |
| 形式 | Liquid |
| 纯化方式 | Affinity purification |
| UNIPROT ID | P16284 |
| 储存缓冲液 | PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. |
| 储存条件 | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
CD31, also known as PECAM1 (Platelet endothelial cell adhesion molecule), is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. It is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, CD31 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).
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的固有成分,如C1-C9、B、D、P因子及MBL相关蛋白,分别参与经典、旁路或凝集素途径,其中C5-C9为共同终末通路分子;二是补体调节蛋白,以可溶或膜结合形式控制活化程度,如C1INH、H因子、DAF、CD59等;三是补体受体,包括CR1-CR5、C3aR、C5aR等,介导补体片段的生物学效应。 补体激活途径 补体系统可通过三条主要途径激活:经典途径、旁路途径和凝集素途径。经典途径由抗原-抗体复合物触发,C1q识别并结合免疫球蛋白(IgM或IgG)的Fc段,在Ca²⁺依赖下激活C1r和C1
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