- ￥870
- Proteintech
- 65286-1-Ig
- 2025年10月09日
- FC
- Mouse
- human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG2b
- 保存条件：
Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Mouse
- 应用范围：
FC
- 靶点：
IL-10
- 抗体英文名：
Anti-Human IL-10 (7B8G3)
- 抗体名：
Anti-Human IL-10 (7B8G3)
- 规格：
100ug
经过测试的应用
| Positive FC detected in | LPS and Brefeldin A treated human PBMCs |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
65286-1-Ig targets IL-10 in FC applications and shows reactivity with human samples.
| 经测试应用 | FC |
| 经测试反应性 | human |
| 免疫原 | fusion protein |
| 宿主/亚型 | Mouse / IgG2b |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | interleukin 10 |
| 别名 | IL-10,IL10, 7B8G3, CSIF, IL 10, IL10 |
| 计算分子量 | 21 kDa |
| GenBank蛋白编号 | BC104252 |
| 基因名称 | IL-10 |
| Gene ID (NCBI) | 3586 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P22301 |
| 储存缓冲液 | PBS with 0.09% sodium azide, pH 7.3. |
| 储存条件 | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
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文献和实验白细胞介素 IL-10 IL-10主要产生细胞：活化T细胞 IL-10氨基酸数目：160 IL-10分子质量(kDa)：17／35 IL-10受体：1L 10Ra；IL-10Pq3 IL-10主要生物学活性：抑制Thl细胞分泌细胞因子；抑制单核细胞、内皮细胞等分泌促炎症因子；抑制单核细胞MHCⅡ类分子和协同刺激分子的表达和NO产生；刺激B细胞增殖和Ig分泌
来瓶「红牛」继续干！唐力团队发现 IL-10 可激活终末耗竭 T 细胞，为增强肿瘤免疫治疗提供新思路
exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity 的研究成果。该研究发现，IL-10 通过上调线粒体丙酮酸载体依赖的氧化磷酸化，从而介导 T 细胞代谢重编程，进而恢复终末耗竭 T 细胞的活力，并增强癌症免疫治疗的反应。 图片来源：Nature Immunology研究内容IL-10 直接扩增终末耗竭的 CD8 + 细胞作者首先制备了重组的人 IL-10 和 IgG1 Fc 的融合蛋白（IL-10–Fc），该蛋白可以与小鼠 IL-10 受体
, cryopreserving, and thawing human PBMCs; and finally, detecting vaccinia-specific IL-10 and IFNγ secreting lymphocytes, as well as CD8+ IFNγ T cells following in vitro stimulation of PBMCs with vaccinia virus. The methods presented below, although optimized
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