- ￥1350 - 3000
- Proteintech
- 19540-1-AP
- 2026年03月03日
- IHC, IF/ICC, ELISA
- Rabbit
- human, mouse, rat
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- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 宿主：
Rabbit
- 应用范围：
IHC, IF/ICC, ELISA
- 靶点：
ZIP kinase
- 抗体英文名：
ZIP kinase Polyclonal antibody
- 抗体名：
ZIP kinase Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive IHC detected in | human stomach cancer tissue, rat colon tissue, rat heart tissue, mouse colon tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HeLa cells, U-251 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:250-1:1000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:20-1:200 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
19540-1-AP targets ZIP kinase in IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | IHC, IF/ICC, ELISA |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | death-associated protein kinase 3 |
| 别名 | DAPK3, Dlk, Death-associated protein kinase 3, DAP-like kinase, DAP like kinase |
| 计算分子量 | 53 kDa |
| 观测分子量 | 37, 52 kDa |
| GenBank蛋白编号 | NM_001348 |
| 基因名称 | DAPK3 |
| Gene ID (NCBI) | 1613 |
| RRID | AB_10860106 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O43293 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Zipper-interacting protein (ZIP) kinase, also known as death-associated protein kinase 3 (DAPK3), is a
serine/threonine kinase that positively regulates mitochondrial-dependent apoptosis as well as autophagy
and acts as a tumor suppressor.
What is the molecular weight of ZIP kinase? Is ZIP kinase post-translationally modified?
The molecular weight of ZIP kinase is 52 kDa. ZIP kinase contains seven phosphorylation sites (six threonine
and one serine residues) that control its activity and localization (PMID: 24193917).
What is the subcellular localization of ZIP kinase?
ZIP kinase contains nuclear localization signal in its C-terminal part. ZIP kinase is present both in the cytoplasm
and in the nucleus. In the cytoplasm ZIP kinase interacts with actin cytoskeleton, regulating contraction of
smooth muscles (PMID: 16005610) and membrane blebbing (PMID: 11781833). In the nucleus it interacts
with several transcription factors regulating gene expression.
What is the tissue expression pattern of ZIP kinase?
ZIP kinase is ubiquitously expressed.
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