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- 文献和实验
- 技术资料
- 免疫原:
Synthesized peptide derived from human IRAK4 around the phosphorylation site of Thr345/Ser346.
- 形态:
liquid
- 保存条件:
Store at -20˚C
- 克隆性:
Polyclonal
- 适应物种:
Human;Mouse;Rat
- 保质期:
12 months
- 抗原来源:
Rabbit
- 供应商:
南京赛戈巍生物科技有限公司
- 宿主:
Rabbit
- 应用范围:
WB
- 靶点:
Uniprot:Q9NWZ3
- 抗体英文名:
IRAK4 (Phospho-Thr345/Ser346) Antibody
- 规格:
50ul/100ul
计算分子量:60 kDa
配方:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
应用详情:
Western blotting: 1:1000-3000
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文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
4 ). 2. Other antibodies used were b-catenin (phospho-Thr41/Ser37/Ser33) (#9561; Cell Signaling Technology), b-catenin (#9562;Cell Signaling Technology), CRMP2 (pT514/509) (#PB-043; Kinasource, Dundee, Scotland) and CRMP2 (#AB-042;Kinasource). 3. Blocking buffer
单抗(canakinumab)。这三种IL-1靶向药物在多种炎症性疾病中展现出良好疗效,安全性总体相似,主要不良反应为轻度非机会性感染风险增加,通常无需停药即可控制。 针对IL-1通路的小分子抑制剂正广泛研发。NLRP3炎症小体作为IL-1β活化关键节点,是主要靶点,如MCC950可有效抑制其激活,降低感染风险。上游靶向P2X7受体或下游靶向caspase-1、IRAK4、MK2等信号分子的抑制剂也在探索中,旨在阻断IL-1生成或信号传导。尽管部分药物因副作用受限,但小分子药物具穿透血脑屏障等优势,为治疗IL-1介导
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