- ￥5444
- BD
- 美国
- 569834
- 2026年10月23日
- Flow Cytometry (FCM)
- Mouse
- Human
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- 文献和实验
- 技术资料
- 供应商：
BD Pharmingen
- 级别：
RUO
- 克隆性：
单克隆
- 抗原来源：
Human
- 标记物：
PE-CF594
- 宿主：
Mouse
- 适应物种：
Human
- 免疫原：
Human PD-L2 cDNA
- 亚型：
Mouse IgG2a, κ
- 形态：
液体
- 应用范围：
Flow Cytometry (FCM)
- 保存条件：
2-8℃避光保存
- 规格：
100 Tests
产品概述
Hu PD-L2(CD273) PECF594 24F.10C12 100Tst 为 BD Pharmingen 品牌流式抗体，货号 569834，荧光标记 PE-CF594，克隆 24F.10C12 (RUO)，规格 100 Tests。适用于 Flow cytometry (Routinely Tested) 检测，仅供科研使用（RUO）。
靶点与抗体说明
The 24F.10C12 monoclonal antibody specifically recognizes Programmed Death Ligand 2 (PD-L2, PDL2) which is also known as CD273, and B7-DC (B7DC). PD-L2 (CD273) is a type 1 transmembrane glycoprotein that is encoded by PDCD1LG2 (programmed cell death 1 ligand 2) which belongs to the B7 family within the Ig superfamily. PD-L2 (CD273) serves as a ligand for CD279, the Programmed Death 1 (PD-1) receptor. CD273 is expressed on dendritic cells, activated monocytes, medullary thymic epithelial cells, placental trophoblasts, and myocardial endothelium. PD-L2 (CD273) can function as a coinhibitor of T cell functions by binding to and signaling through CD279 (PD-1). PD-L2 (CD273) can also reportedly act through another receptor to costimulate T cell activation and cytokine production. The 24F.10C12 antibody can reportedly block the binding of PD-L2 (CD273) to CD279 (PD-1).
核心参数
| 货号 | 569834 |
| 品牌 | BD Pharmingen |
| 克隆号 | 克隆 24F.10C12 (RUO) |
| 宿主 | Mouse |
| 同种型 | Mouse IgG2a, κ |
| 荧光标记 | PE-CF594 |
| 反应种属 | Human |
| 验证应用 | Flow cytometry (Routinely Tested) |
| 推荐用量 | 5 µl/test |
| 免疫原 | Human PD-L2 cDNA |
| 规格 | 100 Tests |
| 存储缓冲液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
荧光染料信息
PE-CF594 BD Horizon™ PE-CF594 dye is a part of the BD PE family of dyes. This tandem fluorochrome is comprised of a R-Phycoerythrin (PE) donor that has excitation maxima (Ex Max) of 496-nm and 566-nm and an acceptor dye with an emission maximum (Em Max) at 615-nm. PE-CF594, driven by BD innovation, is designed to be excited by the blue (488-nm), Green (532-nm) and yellow-green (561-nm) lasers and detected using an optical filter centered near 615 nm (e.g., a 610/20-nm bandpass filter). The donor dye can be excited by the Blue (488-nm), Green (532-nm) and yellow-green (561-nm) lasers and the acceptor dye can be excited by the green (532-nm) laser resulting in cross-laser excitation and fluorescence spillover. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye. 格式:PE-CF594最多激发源:496 nm, 566 nm最多发射源:615 nm
保存与运输
建议 2-8℃ 避光保存，请勿冷冻，避免反复冻融。 存储缓冲液：Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
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，PD-1/PD-L1这么值钱，大家一定好奇它到底是什么鬼。 PD-1全名是程序性死亡分子1(programmed death-1)是Ishida等[1]通过消减杂交技术于1992年发现的[2]，是CD28家族成员，胞质区含有2个酪氨酸残基，1个位于靠近N端的免疫受体酪氨酸抑制基序(ITIM)中，另一个1个位于靠近C端的免疫受体酪氨酸转化基序(ITSM)中[2]。 PD-L1(CD274)是B7家族成员，是PD-1的配体，属于1型跨膜蛋白，全长290个氨基酸，包含1个IgV样
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