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Recombinant Human Protein Kina

se C alpha
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  • ¥987 - 2457
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  • abs44074502
  • 2025年08月28日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

    • 保质期

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    • 英文名

      Recombinant Human Protein Kinase C alpha

    • 库存

      999

    • 供应商

      Absin

    • 规格

      10ug/2ug

    规格:10ug产品价格:¥2457.0
    规格:2ug产品价格:¥987.0

    产品名:

    Recombinant Human Protein Kinase C alpha

    品牌:

    Absin

    货号:

    abs44074502

    保持条件:

    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

    浓度:

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    免疫原:

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    抗原名称:

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    应用:

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    使用方法:

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    产品描述:

        Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
     
        Protein Kinase C alpha Human Recombinant produced in Sf9 is a glycosylated, polypeptide chain containing amino acids 2-672 and having a molecular mass of 76.7 KD. This protein is the full-length form of the protein with an amino terminal poly His-tag.
        PKC-a is purified by proprietary chromatographic techniques.
     
    UNIT DEFINITION:
    7200- 9000 units/mg. One unit of PKC-a activity transfers 1 nmole of phosphate to a PKC substrate peptide (myelin basic protein 4-14) per minute at 30°C. Recombinant human active PKC-a also phosphorylates full length myelin basic protein, histone, MARKS, and GSK-3b. Activity requires incubation with lipid activators, and may vary depending on the substrate and reaction conditions.

    爱必信品牌介绍:

    爱必信(上海)生物科技有限公司是一家从事生物学试剂及耗材的高新技术企业。公司秉承“为生命科学创造便利!为客户创造价值!为员工创造幸福人生!”的发展理念,拥有专业的产品研发质检团队、市场营销团队及先进仓储物流等管理团队。荣获2021年度上海市“专精特新”企业称号。

    自营品牌Absin®,主要经营产品有:生化试剂(常用生化试剂、生物学实验常用试剂、荧光染料、激动剂/抑制剂,植物提取物)、细胞生物学(细胞培养产品、血清、基质胶、添加剂、检测试剂盒)、免疫学产品、分子生物学产品、实验室仪器/耗材、产品定制和检测服务。

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    图标文献和实验
    相关实验
    • Analysis of Protein Kinase C Function

      Protein kinase C is a key element in signal transduction, cell regulation, and tumor promotion, influencing cellular responses to many stimuli at a variety of levels, including receptors, transduction systems, ion channels, and membrane pumps

    • Translocation Assays of Protein Kinase C Activation

      The protein kinase C (PKC) family members include at least 11 different isoforms that, based on their different requirements for activation, have been divided into three subfamilies, the Ca2+ -dependent (cPKCα, (βI , βII

    • 蛋白激酶C(protein kinase C,PKC)

      蛋白激酶C是G蛋白偶联受体系统中的效应物, 在非活性状态下是水溶性的,游离存在于胞质溶胶中,激活后成为膜结合的酶。蛋白激酶C的激活是脂依赖性的,需要膜脂DAG的存在,同时又是Ca2 依赖性的,需要胞质溶胶中Ca2 浓度的升高。当DAG在质膜中出现时,胞质溶胶中的蛋白激酶C被结合到质膜上,然后在Ca2 的作用下被激活。 同蛋白激酶A一样,蛋白激酶C属于多功能丝氨酸和苏氨酸激酶。蛋白激酶C能激活细胞质中的靶酶参与生化反应的调控, 同时也能作用于细胞核中的转录

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