- ￥3000 - 6150
- Solarbio|ActivAb
- 北京
- K011181M
- 2025年08月22日
- FCM
- Mouse
- Human
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- 详细信息
- 技术资料
- 亚型：
IgG2a，κ
- 保存条件：
Store at 4℃ in dark.Do not freeze.
- 克隆性：
Monoclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Mouse
- 应用范围：
FCM
- 浓度：
FCM 5uL/Test.
- 靶点：
TCR CB1
- 抗体英文名：
Anti-TCR CB1(PE) Monoclonal Antibody
- 抗体名：
T细胞受体β恒定1抗体
- 规格：
25T/100T
| 规格： | 25T | 产品价格： | ￥3000.0 |
|---|---|---|---|
| 规格： | 100T | 产品价格： | ￥6150.0 |
| 基本信息 | |
| 英文名称 | Anti-TCR CB1(PE) Monoclonal Antibody |
| 中文名称 | T细胞受体β恒定1抗体 |
| 宿主 | Mouse |
| 克隆类型 | Monoclonal Antibody |
| 亚型 | IgG2a，κ |
| 交叉反应 | Human |
| 应用 | FCM |
| 稀释比例 | FCM 5uL/Test. |
| 密度 | |
| 靶标 | TCR CB1 |
| 别名 | TRBC1;T cell receptor beta constant 1; |
| 背景说明 | Constant region of T cell receptor (TR) beta chain (PubMed:24600447).Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462, PubMed:9382891).The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). |
| Swiss Prot | P01850 |
| 亚细胞定位 | Cell membrane |
| 储存条件 | Store at 4℃ in dark.Do not freeze. |
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K011181M Anti-TCR CB1(PE) Monoclonal Antibody
￥3000 - 6150
