K011684P Anti-JAK3 Polyclonal

【抗体靶点简介】

Non-receptor tyrosine kinase involved in various processes such as cell growth， development， or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm， plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R， IL4R， IL7R， IL9R， IL15R and IL21R. Following ligand binding to cell surface receptors， phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor， creating docking sites for STATs proteins. Subsequently， phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example， upon IL2R activation by IL2， JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then， STAT5A and STAT5B are recruited， phosphorylated and activated by JAK1 and JAK3. Once activated， dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

【实验操作视频参考】

Western blot实验参考操作流程

Immunohistochemistry实验参考操作流程

抗体在科研领域应用十分广泛，对解析生物学过程、探究疾病发病机制、创新药物研发与临床治疗研究均起到关键支撑作用。

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