- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K108935P
- 2025年08月22日
- IHC
- Rabbit
- Mouse;Human
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- 详细信息
- 技术资料
- 免疫原：
A synthetic peptide of Human ZFP36L2
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze/thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Mouse;Human
- 抗原来源：
A synthetic peptide of Human ZFP36L2
- 目录编号：
678
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
IHC 1:25-100.
- 靶点：
ZFP36L2
- 抗体英文名：
Anti-ZFP36L2 Polyclonal Antibody
- 规格：
20ul/50ul/100ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 基本信息 | |
| 英文名称 | Anti-ZFP36L2 Polyclonal Antibody |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Mouse;Human |
| 应用 | IHC |
| 稀释比例 | IHC 1:25-100. |
| 密度 | |
| 靶标 | ZFP36L2 |
| 别名 | BRF2;Butyrate response factor 2;C3H1 type-like 2;EGF response factor 2;EGF-response factor 2;ERF 2;ERF-2;ERF2;Protein TIS11D;RNF162C;TIS11D;TISD_HUMAN;ZFP36 like 2;ZFP36 ring finger protein like 2;ZFP36-like 2;Zfp36l2;Zinc finger protein 36;Zinc finger protein 36, C3H type like 1;zinc finger protein 36, C3H type like 2;Zinc finger protein 36, C3H1 type like 2;Zinc finger protein, C3H type, 36 like 2; |
| 背景说明 | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. |
| Swiss Prot | P47974 |
| Gene ID | 678 |
| 亚细胞定位 | Cytoplasm Cell membrane |
| 免疫原 | A synthetic peptide of Human ZFP36L2 |
| Public Immunogen Range | 220-270/494aa |
| 理论分子量 | 51kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze/thaw cycles. |
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K108935P Anti-ZFP36L2 Polyclonal Antibody
￥480 - 1600
