Rabbit anti-CD44 Recombinant M

别名：兔抗CD44重组单克隆抗体(R107)

免疫原：见优宁维官网

应用：WB: 1:500, IHC-P: 1:1000

保持条件：Store at -20℃ for one year.

使用方法：WB,IHC-P

标记：Unlabeled

宿主：Rabbit

反应种属：见优宁维官网

克隆性：R107

产品描述：

CD44 is a type I transmembrane glycoprotein that mediates cell-cell and cell-matrix interaction through its affinity for hyaluronic acid (HA) and possibly through other parts of the extracellular matrix (ECM). CD44 is highly polymorphic, possesses a number of alternative splice variants and undergoes extensive post-translational modifications (1,2). Increased surface levels of CD44 are characteristic of T cell activation, and expression of the protein is upregulated during the inflammatory response. Interactions between CD44 and HER2 have been linked to an increase in ovarian carcinoma cell growth (1-3). CD44 interacts with ezrin, radixin and moesin (ERM), linking the actin cytoskeleton to the plasma membrane and the ECM (4-6). CD44 is constitutively phosphorylated at Ser325 in resting cells. Activation of PKC results in phosphorylation of Ser291, dephosphorylation of Ser325, disassociation of ezrin from CD44, and directional motility (4).

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