Rabbit anti-VDAC1 Monoclonal A

别名：兔抗VDAC1单克隆抗体(R013)

免疫原：Recombinant protein

应用：WB: 1: 1000,IHC: 1:2000

保持条件：Store at -20℃ for one year.

使用方法：WB,IHC

标记：Unlabeled

宿主：Rabbit

反应种属：见优宁维官网

克隆性：R013

产品描述：

Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria (1). In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics (2). Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c (3). In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3 (4,5).

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